KINGSTOWN, St. Vincent (AP) — La Soufriere volcano fired an enormous amount of ash and hot gas early Monday in the biggest explosive eruption yet since volcanic activity began on the eastern Caribbean island of St. Vincent late last week, with officials worried about the lives of those who have refused to evacuate.

Experts called it a “huge explosion” that generated pyroclastic flows down the volcano’s south and southwest flanks.

“It’s destroying everything in its path,” Erouscilla Joseph, director of the University of the West Indies’ Seismic Research Center, told The Associated Press. “Anybody who would have not heeded the evacuation, they need to get out immediately.”

There were no immediate reports of injuries or death, but government officials were scrambling to respond to the latest eruption, which was even bigger than the first eruption that occurred Friday morning. Roughly 16,000 people who live in communities close to the volcano had been evacuated under government orders on Thursday, but an unknown number have remained behind and refused to move.

The latest explosion is equivalent to the one that occurred in 1902 and killed some 1,600. The volcano last erupted in 1979. Ash from the ongoing explosions has fallen on Barbados and other nearby islands.

St. Vincent’s La Soufriere Volcano earlier today from GOES East pic.twitter.com/Kr23z7ZRZu

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Cots, tents, water tanks and other basic supplies were flooding into St. Vincent as nearby nations rushed to help those affected by the eruptions. At least four empty cruise ships floated nearby, waiting to take evacuees to other islands who have agreed to temporarily receive them, including Antigua and Grenada. All government sea port employees were asked to report

Prime Minister Ralph Gonsalves said in an interview with local station NBC Radio that his government will do everything possible to help those forced to abandon their homes in ash-filled communities.

“It’s a huge operation that is facing us,” he said. “It’s going to be costly, but I don’t want us to penny pinch…this is going to be a long haul.”

Gonsalves said it could take four months for life to go back to normal in St. Vincent, part of an island chain of that includes the Grenadines. The majority of the 100,000 inhabitants live in St. Vincent.

The pandemic also is complicating response efforts. At least 14 new cases of COVID-19 have been reported since the eruptions began on Friday, and all those going to shelters are being tested. Those who test positive are taken to isolation centers. More than 3,700 people are in 84 government shelters.

The eastern Caribbean has 19 live volcanoes, 17 of those located on 11 islands. The remaining two are located underwater near Grenada, including one called Kick ’Em Jenny that has been active in recent years. The most active volcano of all is Soufriere Hills in Montserrat, which has erupted continuously since 1995, destroying the capital of Plymouth and killing at least 19 people in 1997.

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Coto reported from San Juan, Puerto Rico